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Monkeypox is an infectious viral disease that can occur in humans and some animals. Monkeypox symptoms are similar to smallpox symptoms but milder, and include fever, swollen lymph nodes, and a rash. Monkeypox virus, while rarely fatal, is part of the same family of viruses as variola virus, the virus that causes smallpox. Through the second half of May 2022, monkeypox cases in multiple countries outside its endemic area were reported. On May 18, the United States confirmed its first case of monkeypox in 2022.